Abstract
Rotavirus (RV), belonging to Reoviridae family, is the leading cause of acute severe viral diarrhea in children (under 5 years old) and infant animals worldwide. Although vaccines are commonly used to prevent infection, episodes of diarrhea caused by RV frequently occur. Thus, this study was conducted to determine whether resveratrol had protective effects against RV infection in piglets. Following pretreatment with resveratrol dry suspension through adding into the basal diet for 3 weeks, the piglets were orally challenged with RV. We found that resveratrol could alleviate diarrhea induced by RV infection. Resveratrol-treatment inhibited the TNF-α production, indicating that the anti-RV activity of resveratrol may be achieved by reducing the inflammatory response. The IFN-γ level was elevated in 10mg/kg/d resveratrol-treated group and 30mg/kg/d resveratrol-treated group after RV infection. The ratios of CD4+/CD8+ in resveratrol-treated groups were the same as that in mock infected group, suggesting that resveratrol could maintain the immune function in RV-infected piglets. It was found that resveratrol could alleviate diarrhea induced by RV infection. These results revealed that resveratrol dry suspension could be a new control measure for RV infection.
Highlights
Rotavirus (RV) is a double-stranded RNA virus within the family Reoviridae
We found that resveratrol can inhibit duck enteritis virus (DEV) replication in vitro [28] and serve as a control measure for DEV infection in vivo [29]
Severe diarrhea developed in RVC group and the diarrhea index was 2.39
Summary
Rotavirus (RV) is a double-stranded RNA virus within the family Reoviridae. Gastroenteritis induced by RV is the foremost etiological agent of acute pediatric viral diarrhea worldwide which was a leading cause of death among children less than 5 years of age [1]. A recent study indicated that, in total, 127,539 and 53,559 deaths from diarrhea and RV infection respectively, were reported among children younger than 5 years old in China [2]. The immune effects of resveratrol against rotavirus. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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