Abstract
To find natural products showing a protective action against oxidative stress in the brain, extracts of various vegetables were administered i.p. with NMDA via gavage to ICR female mice. Changes in total glutathione, lipid peroxidation and protein oxidation in the brain tissue were examined. When compared to the vehicle-treated control, no significant ( P<0.05) changes in body and brain weight were observed in mice groups administered with either NMDA or vegetable extracts. Administration of NMDA at 80 mg/kg decreased the level of total glutathione. When 20 vegetable extracts were examined for their neuroprotective action, three vegetables, rough aster, sedum and red cabbage, showed the most marked action in restoring glutathione level. In addition, rough aster and red cabbage exhibited a significant ( P<0.05) prevention against the NMDA-induced increase of thiobarbituric acid-reactive substances (TBARS) value in the cytosolic portion of brain homogenate, while their effect on protein oxidation and glutathione-related enzymes was not marked. Based on these results, some vegetable extracts were suggested as functional agents to prevent against oxidative stress in the brain of mice.
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