Abstract
Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices. This, together with recent observations reporting that blue light—also known as high-energy visible light—can exert cytotoxic effects associated with oxidative stress and promote hyperpigmentation, has sparked interest in blue light and its potential harmful effects on skin. The photoprotective properties of new extracts of different botanicals with antioxidant activity are therefore being studied. Deschampsia antarctica (Edafence®, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. In this regard, we studied the protective capacity of EDA against the deleterious effects of artificial blue light irradiation in human dermal fibroblasts (HDF) and melanocytes. We analyzed the impact of EDA on viability, cell morphology, oxidative stress, melanogenic signaling pathway activation and hyperpigmentation in HDF and melanocytes subjected to artificial blue light irradiation. Our results show that EDA protects against cell damage caused by artificial blue light, decreasing oxidative stress, melanogenic signaling pathway activation and hyperpigmentation caused by blue light irradiation. All these findings suggest that EDA might help prevent skin damage produced by artificial blue light exposure from screen of electronic devices.
Highlights
The skin is the main defensive barrier in the body against a large variety of environmental factors and is responsible for maintaining body homeostasis, defence and repair [1]
The terrestrial sunlight spectrum consists of short, high-energy wavelengths, from ultraviolet radiation (UV, 280–400 nm) to visible light (VIS, 400–700 nm), and long, low energy wavelengths: infrared radiation (700 nm–1 mm)
We studied the protective effect of EDA against significant molecular and cellular changes in normal fibroblasts and melanocytes exposed to blue light from artificial electronic devices
Summary
The skin is the main defensive barrier in the body against a large variety of environmental factors and is responsible for maintaining body homeostasis, defence and repair [1]. It is well known that exposure to external factors (e.g., sun radiation, air pollution, tobacco smoke, nutrition and temperature) and internal factors (e.g., sleep deprivation or stress) trigger molecular processes that damage skin structure [2,3]. UV radiation, which is responsible for the majority of harmful effects on the skin, represents just 2%–5% of the terrestrial sunlight [2]. The VIS spectrum represents approximately 50% of the solar spectrum arriving on the earth’s surface, but it was considered to have little impact on skin due to its low energy [4] and received little attention. Recent observations of skin photodamage following VIS exposure and prevention strategies have sparked increased interest [5,6]
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