Abstract
Protective effect of Rhododendron weyrichii flower extract against UVB-induced proinflammatory cytokine production in human keratinocytes
Highlights
The skin is the largest organ in the body and serves as a primary defense against a harmful environment that includes pathogens and ultraviolet (UV) light
The results indicated that the Rhododendron weyrichii flower (RWF) extract inhibited the production of proinflammatory molecules such as IL-6 and tumor necrosis factor (TNF)-α, but not IL-8, in Ultraviolet B (UVB)-irradiated HaCaT cells
Numerous studies have indicated that proinflammatory cytokines such as IL-6, TNF-α, and IL-8 play a role in the immunological regulation of human skin, including skin inflammation
Summary
The skin is the largest organ in the body and serves as a primary defense against a harmful environment that includes pathogens and ultraviolet (UV) light. The present study was undertaken to investigate the protective effects of Rhododendron weyrichii flower (RWF) extracts against UVB damage of immortalized human keratinocytes (HaCaT). To determine the anti-inflammatory effects of RWF, we examined UVB-induced proinflammatory cytokine production in HaCaT cells in the presence or absence of RWF extract, using enzyme-linked immunosorbent assay (ELISA).
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