Abstract
Pracparatum mungo is a traditional and functional food in Traditional Chinese Medicine, especially for treating a variety of liver disorders. In this study, we first report the in vivo hepatoprotective effect of P. mungo extract (PME) on carbon tetrachloride (CCl 4)-induced acute hepatotoxicity in rats. Pre-treatment with PME for 56 days significantly reduced the impact of CCl 4 toxicity on the serum markers of liver damage, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The results were confirmed histopathologically. In addition, an increased lipid hydroperoxide (LPO), a decreased glutathione (GSH) concentration and a decreased superoxide dismutase (SOD) were observed in the hepatic tissues. On the contrary, treatment of PME prior to the administration of CCl 4 resulted in markedly decreased lipid peroxidation, increased the levels of GSH and SOD in rats. The results indicated that PME has a protective effect against acute hepatotoxicity induced by the administration of CCl 4 in rats, and that the hepatoprotective effects of PME may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.
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