Abstract
Purpose: To explore the effect of Radix Bupleuri extract (RBE) on diethylnitrosamine (DEN)-induced liver cirrhosis in rats.Methods: Rats were injected with DEN once a week for 8 weeks to induce liver cirrhosis. Some DENinduced rats were also treated with RBE, which was obtained by extracting dried Radix Bupleuri in water, for 8 weeks. Afterwards, biochemical indices and oxidative stress markers were assessed.Results: RBE significantly decreased serum concentrations of both alanine transaminase (137.3 ± 4.4 U/L, p < 0.01) and aspartate aminotransaminase (152.1 ± 3.4 U/L, p < 0.01) in DEN-induced rats at week 8. In addition, RBE significantly decreased malondialdehyde (0.13 ± 0.02 umol/L, p < 0.01) and superoxide dismutase (0.73 ± 0.04 U/mg protein, p < 0.01) levels in DEN-induced rats (p < 0.01).Conclusion: RBE exhibits a protective effect against DEN-induced liver cirrhosis in rats. Thus, it may have the potential to be used to treat liver cirrhosis in clinical settings.Keywords: Radix Bupleuri, Liver cirrhosis, Anti-oxidant, Diethylnitrosamine, Alanine transaminase, Aspartate aminotransaminase
Highlights
Liver fibrosis is a multi-step process that results from various factors, such as viral hepatitis, alcohol abuse, biliary atresia, and hepatotoxins
[12], this study was performed to investigate the protective effect of Radix Bupleuri extract (RBE) against liver cirrhosis in rats
Group III consisted of liver cirrhosis model rats that were treated with oral RBE (40 mg/kg body weight/rat, once daily) for 8 weeks (RBE group)
Summary
Liver fibrosis is a multi-step process that results from various factors, such as viral hepatitis, alcohol abuse, biliary atresia, and hepatotoxins. The characteristics of liver cirrhosis include cell viability and a decrease in redox ratios, along with reactive oxygen species formation, lipid peroxidation, DNA fragmentation, and apoptotic body formation. All of these factors are potential targets for therapy [2]. [12], this study was performed to investigate the protective effect of Radix Bupleuri extract (RBE) against liver cirrhosis in rats. Group II consisted of liver cirrhosis model rats that were treated with oral saline solution for 8 weeks (model group). Group III consisted of liver cirrhosis model rats that were treated with oral RBE (40 mg/kg body weight/rat, once daily) for 8 weeks (RBE group). Differences were considered statistically significant at p < 0.05
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
