Abstract
The current vaccination for Peste des Petits ruminants PPR is stalled by myriad challenges and continuous endemicity of pneumonia due to fulminant bacteria complication in goats. The present study evaluated the protective effect of intranasal PPR virus linage 1 and bacterine vaccinations. Twelve West African Dwarf goats aged 6 months were randomly grouped and vaccinated within two weeks using combination of PPRV linage 1 vaccine (Nig/75), and bacterine from Mannheimia haemolytica (Mh) or Pasteurella. multocida (Pm) intranasally as A (vaccinated with PPRV & Mh), B (vaccinated with PPRV & Pm), and C (unvaccinated). All the goats were observed for three weeks post vaccination before comingling with a known infected WAD goat showing clinical signs of PPR and further observed clinically for five weeks (35days) post infection. Blood samples were taken for haematology and while sera were assayed for antioxidants (Glutathione Peroxidase GPx, Glutathione Transferase GST, Superoxide Dismutase SOD) activities and prooxidants (Malondialdehyde content, Reduced Glutathione GSH, Hydrogen peroxide H2O2 generation, Myeloperoxidase) using spectrophotometric methods. Data was subjected to parametric statistics at α=0.05 using Graph pad prism version 21. Clinically, there was pyrexia, mucopurulent oculo‐nasal discharge, diarrhoea, anaemia, leucopaenia and increased prooxidants in the unvaccinated goats (C), while moderate neutrophilia and leucocytosis were observed in PPRV and bacterine vaccinated goats. Two unvaccinated goats died at 13 and 28 days post infection. The goats vaccinated with PPRV and Mh showed better response. In conclusion, mucosal vaccination of goats with PPRV vaccine and bacterine will protect against exposure and culminate in the development of protective mucosal, humoral and cell‐mediated immune responses. This vaccination strategy will provide protection needed in the prevention and control of endemic caprine pneumonia in Nigeria.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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