Abstract
About 40 million people in the United States have anxiety disorders, 10 million of which have hypertension. Anxiety is a known contributing factor to hypertension. However, mechanisms responsible for this association are unclear. A causal role of oxidative stress in anxiety‐like behavior and hypertension in rats is known. Oxidative stress also is known to contribute to learning and memory deficits. In this study, using L‐Buthionine‐(S,R)‐sulfoximine (BSO) (300mg/Kg i.p; 7 days), an oxidative stress inducer, we examined the effect of a 2 week treatment of grape powder extract on oxidative stress induced anxiety‐like behavior (open‐field and light dark tests), hypertension and learning and memory function (radial arm water maze test) in rats. BSO treatment increased anxiety‐like behavior of rats and treatment with the antioxidant grape powder prevented this behavior. BSO rats exhibited just as many errors in the short‐term memory test as the grape powder treated rats, but made slightly more errors in the long‐term memory test. Also, BSO rats displayed significantly higher systolic, diastolic, and mean arterial pressure as compared to controls while grape powder treatment prevented BSO‐induced increase in blood pressure. Our studies suggest a potentially protective role of grape powder extract on anxiety‐like behavior, learning and memory function and hypertension in rats.
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