Abstract
Poison ivy (Toxicodendron radicans), poison oak (T. diversilobum), and poison sumac (T. vernix) are the primary causes of contact dermatitis in the United States, affecting 10–50 million Americans every year. The prevalence of sensitivity to poison ivy and poison oak in the general adult population ranges from 50% to 70% with peak frequency for sensitization occurring between the ages of 8 and 14. Outdoor activities as well as outdoor occupations which relate to firefighting, forestry and agriculture are at high risk, costing significant medical expenses and worker's disability. During our ongoing studies aimed at the discovery of an effective prophylactic treatment for toxicodendron dermatitis, we have developed a series of novel agents and tested the efficacy of these agents in an in vivo animal model. Here, we present the protective effect of our pro-drug ELI-21C-76C in our guinea pig experimental model.
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