Abstract
The effect of coenzyme Q 10 administration on exercise-induced muscular injury was examined in rats. Coenzyme Q 10-treated and control rats were exercised by 90 min of downhill treadmill running. A part of the animals in both groups were killed immediately after exercise and the others were 40 h postexercise. After the exercise bout, serum creatine kinase and lactate dehydrogenase activities were elevated in the control rats, but not in the coenzyme Q 10-treated rats. These enzyme activities in the latter increased to the similar level of the former 40 h postexercise. The muscle coenzyme Q 10 content increased by the coenzyme Q 10 treatment. These results suggest that the coenzyme Q 10 treatment protected skeletal muscles against injury caused during exercise, but not against damage related with inflammatory processes after exercise.
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