Abstract
This study was aimed at evaluating the hepatoprotective activity of Canavalia gladiata seed extract in azathioprine (AZP) intoxicated rats. AZP (1 mg/ml i.p.) was administered for 22 days to induce hepatotoxicity in Wistar rats. Canavalia gladiata seed extract was prepared using methanol and water. The methanolic extract of Canavalia gladiata at a dose of 100 or 200 mg/kg was used to determine hepatoprotective activity by measuring liver tissue damage markers like serum glutamic pyruvic transaminase, glutamic oxaloacetate transaminase, alkaline phosphatase, and bilirubin levels. The levels of these markers were markedly decreased compared to the AZP group. Canavalia gladiata seed extract doses of 100 and 200 mg/kg significantly reduced AZP-induced hepatotoxicity and these results were supported by histopathological findings. Data indicate the hepatoprotective activity of natural herbal extract in hepatocytes of AZP-treated rats.
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