Abstract
IntroductionIrradiation is known to cause oxidation process among the tissue-altering the properties of teeth leading to tissue necrosis and caries formation. Hence protection of the oral cavity is a major concern to deal with therapy side effects.AimEvaluation of wear resistance property of Enamel against electron beam radiation and analysing the radio protective effects of natural organic compounds.Materials and methodsTotal of 36 healthy extracted human molar teeth were collected, four samples were used as control, and remaining 32 were divided into four groups (N = 8 each): radiation control group and three groups treated with organic compounds during radiation treatment. The enamel samples were tested for FTIR spectroscopy, XRD analysis, SEM and EDAX analysis before and after 70 Gy radiation treatment.Results and discussionThe particle size of radiation control samples had increased showing decrease in its crystallinity index. Calcium to Phosphorous ratio had also decreased along with structural changes as observed by SEM analysis. But groups treated with organic compounds has maintained tooth integrity in comparable to control groups after radiation treatment.ConclusionVirgin coconut oil, vitamin E oil and curcumin has potential radioprotective action against radiation in protecting tissue properties. Hence, with further advanced research, these natural substances should emerge as a topical applicator during radiotherapy to oral cancer patients.
Highlights
Irradiation is known to cause oxidation process among the tissue-altering the properties of teeth leading to tissue necrosis and caries formation
Four samples were used as control, remaining 32 samples were divided into four groups (N = 8 each) based on the topical application used for protection during irradiation treatment: (1) radiation control group in distilled water, (2) test group in coconut oil, (3) test group in vitamin E oil and (4) test group in turmeric
Virgin coconut oil Vitamin E oil SEM and EDAX analysis The Scanning Electron Microscopy (SEM) images of normal perpendicular sectioned enamel showed clear prisms surrounded by inter prismatic region before radiation
Summary
Irradiation is known to cause oxidation process among the tissue-altering the properties of teeth leading to tissue necrosis and caries formation. The aggressive mode of treatment against the oncological condition has unavoidable effects on normal cells within the vicinity of exposure.[5] It mainly affects salivary glands leading to xerostomia, muscular atropy, dental caries, fungal and bacterial infections and many more.[6] Radiation caries is the late indirect effect observed in the patients causing irreversible damage on the dental tissues.[7] Evidence suggest that demand for dental treatment is around 58–98% among oral cancer patient[8] dental treatments are highly recommended in prior to prevent post radiation effects, especially to extract teeth with poor prognosis having high risk of infection.[8] Because, there are high possibility to develop caries or osteonecrosis in irradiated teeth due to softening of the tissue, plaque formation[9] and changes in dental tissue properties decreasing surface microhardness (SMH),[7,10] ultimate tensile strength[11] and fracture resistance.[12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
