Abstract
Benign prostatic hyperplasia (BPH) is a common urological disorder of men, characterized by prostatic enlargement and urethral obstruction. In this study, BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for 3 weeks. Tetracarpidium conophorum was administered daily by oral gavage at a dose of 100, 200 and 400 mg/kg BW of extract for three weeks, along with the TP injections and 5 mg/kg of finasteride for comparison. On day 21, the animals were sacrificed after anesthesia. Prostate were excised, weighed and used to determine relative prostate weight. Quantitative and qualitative phytochemical screening was also done and it showed the presence of flavonoids (0.370 mg/ml), tannins (0.458 mg/ml), phenols (0.508 mg/ml) and steroids (0.257 mg/ml). The prostate specific antigen level was evaluated, the result showed the data for extract group 200 mg/kg, 400 mg/kg, finasteride control group and BPH control group to be 0.186 ± 0.0023 ng/ml, 0.153 ± 0.005 ng/ml, 0.119 ± 0.0125 ng/ml and 0.332 ± 0.004 ng/ml respectively.
Highlights
Prostate specific antigen and relative prostate weight data on effect of Tetracarpidium conophorum leaf extract on testosterone-induced benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for 3 weeks
The prostate specific antigen level was evaluated, the result showed the data for extract group 200 mg/kg, 400 mg/kg, finasteride control group and BPH control group to be 0.186 7 0.0023 ng/ml, 0.153 7 0.005 ng/ml, 0.119 7 0.0125 ng/ml and 0.332 7 0.004 ng/ml respectively. & 2018 The Authors
Summary
Relative prostate weight determination in experimental animals Relative prostate weight is used to evaluate the growth of benign prostatic hyperplasia in males (Table 3). Normal control BPH control 100 mg/kg Tetracarpidium conophorum 200 mg/kg Tetracarpidium conophorum 400 mg/kg Tetracarpidium conophorum Finasteride control a values differ significantly from normal control group. B values differ significantly from BPH control group. Determination of prostate specific antigen in blood plasma of experimental animals Prostate specific antigen (PSA) is found in blood serum when it is increased due to the presence of prostate diseases. A Values differ significantly from normal control. B Values differ significantly from BPH control. The leaves were picked from the branch, air dried and ground to powdered form before use. The pulverized leaves were weighed (600 g), soaked for 3 days in 80% ethanol, sieved and extracted (32 g) using a rotary evaporator
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