Abstract
The effect of PGE 2, PGI 2, and 6-keto-PGF 1α respectively on the contractile response of the isolate , field-stimulated guinea pig vas deferens was investigated. All three PGs were capable of inhibiting the contractile responses of the vas deferens, but the concentrations required varied considerably: PGE 2 was about 700 times more active than PGI 2 and about 4600 times more active than 6-keto-PGF 1α in this respect. It is suggested that PGI 2, although formed in tissues with sympathetic innervation, does not play a physiological role as inhibitor of sympathetic transmitter release.
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