Abstract
1. 24Na studies indicate that the ionic basis of the increase in SCC across isolated frog skin ( Rana temporaria) following prostaglandin E 1 application, is an increase in gross sodium influx, with sodium efflux remaining unchanged. 2. In the first 15 min prostaglandin E 1 caused a decrease in net water inflow across frog skin. The time-course of this initial effect was similar to that observed for adrenaline, but it was unaffected by propranolol. In the second 15-min period net water inflow returned to the control level. In those skins where prostaglandin E 1 produced a substantial rise in SCC an increase in net water inflow was seen. 3. HTO studies revealed that prostaglandin E 1 also produced a significant increase in water influx across the skin. 4. It is concluded that the initial effect of prostaglandin E 1 on net water flow can be attributed to glandular secretion and the subsequent effect to stimulation of sodium transport.
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