PROSPECTS OF MAGNETOLASER THERAPY APPLICATION IN TREATMENT OF EXPERIMENTAL NEUROPATHY

Abstract

The aim of the work is to establish morpho-functional changes of the conducting apparatus of the extracranial part of the rabbit's facial nerve at experimental neuropathy and its correction by magneto-laser therapy.Materials and methods. The material for the study was the extracranial part of the facial nerve (FN) of 15 rabbits, of which 5 intact animals, 5 - were simulated experimental cold neuropathy, 5 - with neuropathy combined with the action of a permanent electromagnetic field and laser radiation. Histologic (coloring by Kulchytsky, Marky, Masson, Renson), electron microscopic methods of research, electroneuromyography and morphometry with statistical processing of data were used.Results. In the process of development of cold neuropathy FN, we have isolated a stage of reactive-dystrophic changes. In most myelinated nerve fibers, uneven coloration, significant edema and destruction of the myelin sheath with axon exposure and the accumulation of myelin residues in the cytoplasm of the neurolemocyte are observed. The number of small and medium-sized ones decreases and the number of large myelinated nerve fibers (NF) increases. A consequence of demyelination of individual axons is an increase in the number of demyelinated NF. At this stage, the amplitude of the M-response decreases; there is a decrease of the amplitude and increase of the latent period of the F wave, and its polyphasicity, while the pulse rate reduction (PRR) is 79.3%, that is indicating a deep morpho-functional reorganization of the nerve conductors.Activation of phagocytosis processes takes place magnetolaser therapy in result of which facilitates the removal of the decay products, which were formed as a result of cold trauma and ischemia, already by 10 days. It reduces the time of demyelination and promotes the activation of remyelinisation processes by improving blood supply. This is confirmed by minor qualitative, quantitative and metric changes in the conducting apparatus of the damaged FN. The electroneuromyographic indicators significantly improve: the speed of impulses in the proximal and distal regions increases, the H-reflex threshold and the ratio of its maximum amplitude to the M-response are more likely to increase, the amplitude increases and the latent period of the F-wave is shortened.Conclusions. Magneto-laser therapy is effective in the treatment of experimental LN neuropathy, since it restores the structural organization of the hemocirculatory system, normalizes the permeability of the vascular wall, which accelerates the utilization of myelin degradation products, improves nutrition of NF and their remyelination.