Abstract

Hypothalamic amenorrhea (HA) and polycystic ovarian syndrome (PCOS) are well-defined aetiologies of female infertility. Both can be associated in some women (HA/PCOS), but this has not been largely described. The ovarian hyperandrogenism in HA/PCOS is masked by suppressed hypothalamic-pituitary axis. Ovulation induction with FSH or hMG in HA/PCOS women often leads to inadequate ovarian response. The aim of this study was to compare pulsatile GnRH therapy and gonadotropins FSH + LH treatment for ovulation induction in HA/PCOS women.

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