Abstract
BackgroundIn the present matched-cohort study, we investigated the efficacy of olanexidine gluconate in comparison with chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy.MethodsA total of 372 patients with esophageal cancer who were scheduled to undergo thoracic esophagectomy between 2016 and 2018 were assigned to one of two groups based on the preoperative antiseptic agent used in thoracic esophagectomy. We investigated the incidence of surgical site infectious complications in the propensity-matched cohort.ResultsBased on the propensity score, 116 patients prepared with 1.5% olanexidine gluconate and 114 patients prepared with 1.0% chlorhexidine-alcohol as surgical skin antisepsis were selected. No significant intergroup differences were observed with respect to incisional surgical site infection (0.8% in the olanexidine group versus 0.8% in the chlorhexidine group) and deep fascial/organ space surgical site infection (1.7%/10.3% in the olanexidine group versus 3.5%/15.7% in the chlorhexidine group, p = 0.39/p = 0.03). Notably, the respective incidences of surgical site infection except anastomotic leakage were 1.7% and 7.0% in the olanexidine and chlorhexidine groups (p = 0.04).ConclusionsOlanexidine gluconate was well tolerated and significantly reduced incidence of surgical site infection except anastomotic leakage in comparison with chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy with three-field lymph node dissection.
Highlights
In the present matched-cohort study, we investigated the efficacy of olanexidine gluconate in comparison with chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy
We retrospectively investigated the incidence of surgical site infection (SSI) and performed a propensity matched-analysis to compare the efficacy of olanexidine gluconate versus chlorhexidinealcohol in clean-contaminated surgery, in patients with esophageal cancer undergoing thoracic esophagectomy
There were no significant differences between the chlorhexidine-alcohol and olanexidine gluconate groups with respect to baseline patient characteristics, including age, sex, body mass index, ASA grade, preoperative treatment, and clinical stage of the disease before adjusting (Table 1)
Summary
In the present matched-cohort study, we investigated the efficacy of olanexidine gluconate in comparison with chlorhexidine-alcohol as an antiseptic agent in thoracic esophagectomy. Olanexidine (Olanedine; Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan), containing 1.5% olanexidine gluconate, is a new skin antiseptic agent that was approved in Japan in 2015. Recent randomized control studies have demonstrated that olanexidine significantly reduces SSI compared with povidone iodine in clean-contaminated surgery [5, 9]. It is unknown whether olanexidine is superior to chlorhexidine-alcohol in preventing SSI in clean-contaminated surgery. We retrospectively investigated the incidence of SSI and performed a propensity matched-analysis to compare the efficacy of olanexidine gluconate versus chlorhexidinealcohol in clean-contaminated surgery, in patients with esophageal cancer undergoing thoracic esophagectomy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
