Abstract

Prolonged Incubation Period for<i>Cryptococcus gattii</i>Infection in Cat, Alaska, USA

Highlights

  • Cryptococcus gattii (Cg) is a fungus that is commonly isolated from the environment in tropical and sub-tropical regions globally

  • Cases of cryptococcosis have been documented in Alaska, details about the method of diagnosis, specific fungal variant, presence of comorbidities, or travel history were not routinely collected

  • In 2008, Cg infection was confirmed in an Alaska resident who had significant travel to Washington and Oregon.[3]

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Summary

Background

Cryptococcus gattii (Cg) is a fungus that is commonly isolated from the environment in tropical and sub-tropical regions globally. In contrast to the more commonly-occurring Cryptococcus neoformans infections, Cg is more likely to infect patients without HIV infection and to cause cryptococcomas (tumor-like granulomatous lesions), and is less responsive to antifungal drugs.[2,3] Infection with Cg can be asymptomatic or, after an incubation period that can be as long as 13 months, cause a range of symptoms including chest pain, cough (often lasting weeks to months), fever, headache, meningitis, nausea/vomiting, night sweats, shortness of breath, and weight loss. Because Cg appears to have adapted to a new climatic niche in the Pacific Northwest,[3] further work is warranted to better understand the potential extent of the organism’s ecological range. This will be important for Alaska if our temperature trends continue to rise.[5]

Surveillance for Human Cases in Alaska
Surveillance for Animal Cases in Alaska
Environmental Sampling
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