Abstract
We report here an extremely rare case of proliferative Brenner tumor with borderline mucinous cystadenocarcinoma of the ovary, metastasizing to the pleura in a 75-year-old woman. Massive pleural effusion were present due to metastasis and pseudo-Meigs’ syndrome. The cytological findings from pleural effusion, ascites and tumor imprint were similar, suggesting mucus-producing malignant tumors. After receiving a thoracic drainage for pleural effusion, the patient underwent an exploratory laparotomy to remove the left-ovarian tumor. Histopathological examination revealed proliferative Brenner ovarian tumor with borderline mucinous cystadenocarcinoma, and immunohistochemical examinations for the tumors, even mucus-rich tumor cells were positive for CK 7 and negative for CK 20, suggesting the tumor arising from transitional cells, not from mucus-producing ovarian surface epithelial tumor cells. She underwent four courses of chemotherapy with paclitaxel and carboplatin. The patient showed no signs of recurrence 16 months after the surgery.
Highlights
Brenner tumors (BTs) of the ovary are rare epithelial tumors that account for 1% - 2% of all ovarian neoplasms
We present here an extremely rare case of proliferative BT with borderline mucinous cystadenocarcinoma of the ovary in a 75-year-old woman, in which immunohistochemistry of CK 7 and CK 20 was useful for the diagnosis
Ovarian BTs are rare adenofibromas that account for 1% - 2% of all ovarian neoplasms
Summary
Brenner tumors (BTs) of the ovary are rare epithelial tumors that account for 1% - 2% of all ovarian neoplasms. Proliferative BT of the ovary was first described in 1971 by Roth and Sternberg [1], and was confirmed by Miles and Norris [2]. The terms of borderline malignancy and proliferating in reference to BTs were equated in the WHO publication [3] It is a separate category of BT, being intermediate in its histologic appearance and biological aggressiveness compared with benign and malignant types of BTs [2][4][5]. We present here an extremely rare case of proliferative BT with borderline mucinous cystadenocarcinoma of the ovary in a 75-year-old woman, in which immunohistochemistry of CK 7 and CK 20 was useful for the diagnosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
