Abstract
Per oral mucosal biopsies obtained from the body and pyloric antrum of normal stomachs and from the body of atrophic stomachs of pernicious anemia patients were studied by light and electron microscopy. The atrophic mucosae contained numerous endocrine-like (enterochromaffin) cells both in the islets of ectopic intestinal epithelium and in the nonintestinalized atrophic glands. The proliferation of such cells, which metabolize pharmacologically potent amines and peptides, probably plays a significant role in the physiology of these stomachs.
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