Abstract
PRL involvement in periparturient mammary development and onset of milk secretion was studied in 17 multiparous, monotocous Holstein cows. Mammary glands were obtained 10 days prepartum from untreated cows and 10 days postpartum from untreated cows and cows treated with CB154 (2-Br-α-ergokryptin) or CB154 plus PRL. CB154 was administered for 12 days before expected parturition through 10 days postpartum. PRL was infused continuously for 6 days immediately before parturition in cows receiving CB154 plus PRL. Treatment with CB154 reduced basal serum PRL concentrations approximately 80% and blocked the normal surges in serum PRL concentrations at parturition and during milking. Average milk production in cows given CB154 alone was 11.4 kg/day lower than in controls. Periparturient infusion of PRL in cows treated with CB154 (CB154 plus PRL) prevented reductions in milk production. Treatment with CB154 had no effect on feed intake or periparturient serum concentrations of GH, progesterone, and glucocorticoids....
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