Abstract
JC virus can exist in latent state in human bodies of many people. It can be activated in subjects with immunodeficiency and manifest with progressive multifocal leukoencephalopathy (PML) and some other neurological symptoms of central nervous system disorder. Most frequently people with AIDS suffer from JC virus. Reactivation of JC virus has recently been seen on immunosuppressive therapy. The article presents literature review of clinical and neuroimaging symptoms of PML associated with high-active HIV antiretrovirus therapy and natalizumab therapy of multiple sclerosis. The article also presents the inflammatory syndrome of immunity recovery.
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