Abstract
The encephalopathy of prematurity is a complex amalgam of primary destructive disease and secondary developmental disturbances.The interrelations between destructive and developmental mechanisms at cellular and molecular level in the genesis of the encephalopathy are emphasized and reviewed.We focus on its latest definition,microglia activation induced oligodendrocyte injury,neuronal/axonal impairments,and recent insights of thalamus,subplate neurons and cerebral cortex injury. Key words: Prematurity; Encephalopathy; Mechanisms; Developmental disturbances
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