Progress in the Study of Significant Mutated Genes and Molecular Biological Factors in Cervical Tumors

Abstract

Cervical cancer is the most prevalent gynecologic malignancy in developing countries, with incidence and mortality rates continuing to rise. Despite widespread research on cervical cancer, the specific mechanisms and synergistic factors underlying its occurrence remain unclear. In recent years, there has been a growing interest in the relationship between gene mutations and cervical cancer. Numerous studies have demonstrated that alterations in oncogenes, tumor suppressor genes, and related regulatory genes are closely associated with the development and progression of cervical cancer. The application of genome sequencing technology in malignant tumors has allowed for the identification of additional gene mutations in cervical cancer. By identifying significantly mutated genes, we can further target malignancy driver genes, which may be the key to uncovering the intrinsic mechanisms of sexual tumors. Therefore, a review of the current status of research on mutated genes in cervical cancer and factors associated with recurrence after treatment of early-stage cervical cancer can provide new insights for mechanistic studies, diagnosis, and targeted therapy of cervical cancer.