Abstract
CD33rSiglecs (CD33-related sialic acid binding immunoglobulin-like lectins)are members of the Siglecs family which mediate sialic acid-dependent cellular interactions and may some cases play important role in signal transduction. In addition to the previously characterized Siglecs, sialoabdesins, CD22, CD33, myelin-associated glycoprotein and several CD33rSiglecs have recently been cloned. Although these novel re-ceptors have gained considerable interest as therapeutic targets because of their expression on immune cells, very little is known about the activities of these lectins and how they are regulated. Previous studies on sialoadhesin, CD22 and CD33 have shown that Siglec glycosylation has significant effects on the binding to the their ligands. In this review, we summarized the recent research results about CD33rSiglecs members on protein sequences, ligand patterns, gene structures, expression patterns and function. Key words: CD33 ; Sialic acid; Immunoglobin; Lectin
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