Progress in the degradation relationship between macrophages and composite stent materials

Abstract

Bone tissue engineering is increasingly used in the repair of maxillofacial bone defects. The application of composite materials can make up for some of the shortcomings of single materials in the past, such as insufficient strength of single materials, poor biocompatibility, and degradation of biomaterials. Some problems, in which the degradation rate of composite materials in vivo does not match the rate of bone formation, is one of the main clinical problems faced by bone tissue engineering bone composite scaffold materials. The degradation of materials in vivo is mainly divided into two aspects: biological and chemical degradation. The participation of cells is an important part of biodegradation. Among them, the role of macrophages has attracted more and more attention. It can affect the degradation of materials through direct contact with the material itself or by secreting different factors. A good understanding of the mechanism of macrophages in material degradation helps us to better design and manufacture composite scaffold materials with a degradation rate that matches the bone formation in vivo.