Abstract

近几年来,肺鳞癌在化疗及靶向治疗上的进展不够显著,但免疫治疗却在肺鳞癌的治疗上取得了突破性的进展。免疫治疗通过免疫系统来清除肿瘤细胞,主要分为免疫检查点抑制剂及治疗性疫苗。免疫检查点抑制剂,包括抗细胞毒性T淋巴细胞抗原4(cytotoxic T-lymphocyte associated antigen 4, CTLA-4)抗体与抗程序性死亡受体-1(programmed death receptor 1, PD-1)抗体等多种药物已进行了肺鳞癌的Ⅱ期、Ⅲ期临床试验,并取得了一定成果。免疫治疗将成为肺鳞癌治疗的一种重要手段。

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