Abstract

Evolution in breast cancer surgery has been significant over these four decades. Many scientific changes have been reached, impacting daily clinical practise, thanks to scientific research and surgeons' efforts, always tended to warrant oncological radicality as well improve women quality of life and cosmesis. Achievements in imaging, in breast cancer molecular signature characterization and patients' genomic profile are progressively refining a sophisticated personalization of breast cancer prevention and treatment. Progress in surgery involves both primary breast site surgery and surgical axillary staging, revealing a strong propensity for a limited surgical approach and technical precision. Multimodal management and individualization are the axioms on which current research on breast cancer prevention and treatment is progressing.

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