Prognostic Value of the Degree of Tumor Tissue Infiltration by CD15-Positive Granulocytes in Nodular Sclerosis Classical Hodgkin’s Lymphoma

Abstract

Nodular sclerosis classical Hodgkin’s lymphoma (NSCHL) is one of the most common malignant lymphoproliferative diseases among younger people. The tumor is considered to be potentially curable. However, despite successful application of standard treatment methods, primary resistance and relapses occur. At present, many researchers focus on studying the value of tumor microenvironment in the prognosis of the course and progression of classical Hodgkin’s lymphoma (cHL), aiming at identifying new therapeutic targets. The present paper shows that the relative count of CD15-positive granulocytes in patients with favorable course of the disease is significantly lower than in therapy-refractory patients. The threshold of tumor microenvironment cells expressing CD15 was 8 %. The data obtained provide the basis for determining prognostic value of CD15-positive granulocytes in NSCHL and presenting this cell pool as a potential therapeutic target.