Abstract
Objective To evaluate the prognostic value of lncRNA PVT1 for patients with gastric cancer. Methods A comprehensive literature searching was performed in PubMed, Cochrane Library, Web of Science, Embase, CNKI, CBM, and Wanfang Database to identify published studies on the expression level of lncRNA PVT1 in human gastric cancer. STATA 12.0 was conducted to perform the meta-analysis. Clinical outcomes including patients' age, genders, TNM stage, OS, and DFS were assessed in the study. Results A total of 8 studies involving 747 patients were included in this meta-analysis. The results of meta-analysis showed that higher expression level of lncRNA PVT1 was associated with GC patients' gender (for male: OR = 2.27, 95% CI: 1.67~3.07, P = 0.000), invasion depth (for T3~4: OR = 3.98, 95% CI: 2.85~5.56, P = 0.000), poorer OS (HR = 1.68, 95% CI: 1.43~1.97, P = 0.000), and DFS (HR = 1.74, 95% CI: 1.44~2.08, P = 0.000). Conclusion Higher expression level of lncRNA PVT1 is significantly associated with GC patients' gender, invasion depth, poorer OS, and worse DFS. lncRNA PVT1 might act as a novel predictive biomarker of poor prognosis and clinicopathological characteristics for gastric cancer.
Highlights
Long noncoding RNAs are a class of RNA molecules with a length of more than 200 nucleotides [1]
Inclusion criteria were as follows: (1) all studies were published in English and Chinese, and full text is available on the online databases; (2) patients were diagnosed with gastric cancer in any TNM stage; (3) the expression level of Long noncoding RNAs (lncRNAs) plasma tumor variant translocation 1 (PVT1) was reported in studies, and lncRNA PVT1 was detected by established molecular methods, such
The results showed that high expression level of lncRNA PVT1 was associated with male gender (OR = 2:27, 95% confidence interval (95% CI): 1.67~3.07, P = 0:000) (Figure 3)
Summary
Long noncoding RNAs (lncRNAs) are a class of RNA molecules with a length of more than 200 nucleotides [1]. Due to the lack of open reading frames, they cannot encode proteins. They were considered as “junk sequences” in the process of gene transcription [2]. LncRNAs do not encode proteins, they can still regulate gene expression through a variety of mechanisms at the epigenetic, transcriptional, and posttranscriptional levels, which become one of the research hotspots in recent years [3]. A large number of studies have shown that lncRNAs play an important role in the invasion, migration, and metastasis of tumors [4, 5]. Plasma tumor variant translocation 1 (PVT1) was reported as a key biomarker of prognosis for patients with gastric cancer (GC) [6]
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