Abstract
Background Midwall septal fibrosis on late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging has been shown to be an independent predictor of adverse events in patients with non-ischemic dilated cardiomyopathy (NICM). Recent studies in other cardiomyopathy cohorts, such as Hypertrophic Cardiomyopathy, suggest that LGE extent provides incremental prognostic value over its binary presence or absence. The objective of this study was to investigate the prognostic value of septal LGE quantification for the prediction of arrhythmic events among patients with NICM.
Highlights
Midwall septal fibrosis on late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging has been shown to be an independent predictor of adverse events in patients with non-ischemic dilated cardiomyopathy (NICM)
Septal LGE mass was significantly higher among those having an event versus those without (4.53±4.54g vs 1.73±2.48g, p=0.014, HR 1.2 per 1g)
Multivariate analysis inclusive of the 2 variables of Septal LGE mass and LVEF showed Septal LGE mass to be an independent predictor of the primary outcome (HR 1.23 per 1g, p
Summary
Midwall septal fibrosis on late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging has been shown to be an independent predictor of adverse events in patients with non-ischemic dilated cardiomyopathy (NICM). Recent studies in other cardiomyopathy cohorts, such as Hypertrophic Cardiomyopathy, suggest that LGE extent provides incremental prognostic value over its binary presence or absence.
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