Abstract
Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.
Highlights
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies worldwide, and the major factor contributing to its poor prognosis and CRC-related death is the development of lymph node and/or distance metastases [1]
We summarize the current main opinions regarding the characteristics of periostin in metastatic process and discuss its prognostic functional roles in CRC
Stromal periostin secretion dose-dependently predicted the poor prognosis of CRC patients who underwent postoperative chemotherapy
Summary
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies worldwide, and the major factor contributing to its poor prognosis and CRC-related death is the development of lymph node and/or distance metastases [1]. The N-terminal region contains a signaling peptide to promote periostin secretion and regulates cell functions by binding to integrins at the plasma membrane via FAS domains [19,20]. The FAS-1 domain in the N-terminal region of periostin acts as a ligand for integrins, inducing metastasis via the activation of protein kinase B (Akt/PKB) signaling in cancer cells [12,36].
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