Abstract
AbstractWe evaluated the prognostic factors in patients with colorectal liver metastases undergoing radiofrequency ablation (RFA). Between 2008 and 2013, 52 patients (males 34, mean age: 63 years) with colorectal liver metastases treated with either percutaneous RFA (n = 33) or intraoperative RFA plus resection (n = 19) were enrolled. Cumulative incidence of new recurrence was estimated using the Kaplan‐Meier method. The prognostic relevance of clinical variables and recurrence or survival were evaluated using the log‐rank test and multivariate Cox's regression analysis, respectively. Primary technical success was achieved in 45 (87%) of the cases. There were no procedure‐related deaths. Multinodularity (>3) (P = 0.001) predicted higher incidence of developing new recurrence after RFA. Overall 1‐, 2‐, and 3‐year survival from RFA was 87%, 61%, and 46%, respectively. Factors associated with overall mortality were age younger than 60 years (P = 0.036), extrahepatic metastasis (P = 0.003), and carcinoembryonic antigen (CEA) level ≥10 ng/mL before RFA (P = 0.011). Multivariate Cox's regression analysis showed that young age (<60 years) and high CEA level (≥10 ng/mL) were independent factors associated with overall survival. RFA for colorectal liver metastases is an effective treatment option. Young age and high CEA level predicted poorer outcomes after RFA.
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