Prognostic factors for patients who underwent surgical treatment for huge liver cancer

Abstract

Objective To analyze the prognostic factors for patients who underwent surgical resection for huge liver cancer so as to improve the medical results of comprehensive therapy.Methods We retrospectively arlaysed the data of 51 patients who underwent surgical resection for huge liver cancer.Fifteen clinicopathologic factors possibly influencing survival were selected,and multivariate analysis of these parameters was performed using the Cox proportional hazards model.Survival analysis was done using the KaplanMeier method.Results The overall 1-,3-,5-year survival rates of 50 patients were 75.8％,37.9％ and 21.1％,respectively.Univariate analysis showed that AFP over 400 μg/L,tumor diameter over 12 cm,tumor boundary,vascular invasion and TNM staging significantly affected postoperative survival.Cox multivariate analysis indicated that tumor diameter of ≥ 12 cm,tumor boundary and vascular invasion were independent prognostic factors.Univariate analysis showed that tumor boundary,vascular invasion and TNM staging were the independent factors affecting recurrence,Cox multivariate analysis showed that vascular invasion was an independent factor influencing recurrence of tumor.Conclusions Surgical resection for patients with huge liver cancer could be safely performed with reasonable long-term survival.For patients having tumors with poor prognostic factors,there is a need for effective adjuvant therapy. Key words: Liver cancer; Hepatectomy ; Prognosis