Abstract
BackgroundMany studies have investigated the prognostic role of E-cadherin in patients with NSCLC; however, the result still remains inconclusive. An up-to data system review and meta-analysis was necessary to give a comprehensive evaluation of prognostic role of E-cadherin in NSCLC.MethodsEligible studies were searched in Pubmed, Embase and Web of Science databases. The inclusion criteria were studies that assessed the relationship between E-cadherin expression detected by immunohistochemistry (IHC) and the prognosis or clinicopathological features in patients with NSCLC. Subgroup analysis according to race, percentage of reduced/negative E-cadherin expression, histological type, and sample size were also conducted. Odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI) were calculated to examine the risk or hazard association.ResultsA total of 29 studies including 4010 patients were qualified for analysis. The analysis suggested that downregulated E-cadherin expression was significant associated with unfavorable overall survival (OS) and disease-free survival/progression-free survival (DFS/PFS) in patients with NSCLC. Subgroup analysis by race, percentage of reduced/negative E-cadherin expression, sample size also found the significant association in OS. When only the stage I NSCLC were considered, downregulated E-cadherin expression still had an unfavorable impact on OS. Additionally, downregulated E-cadherin expression was significantly associated with differentiation grade, lymphnode metastasis, vascular invasion, and TNM stage.ConclusionDownregulated E-cadherin expression detected by IHC seems to correlate with tumour progression and could serve as an important prognostic factor in patients with NSCLC.
Highlights
Lung cancer still remains the most common cancer and the most common cause of cancer-related death worldwide
Eligible Studies The present work followed the guidelines for systematic reviews and meta-analyses (PRISMA) (Checklist S1). 423 articles were identified from three databases
The remaining 46 articles were further checked by screening the full texts. 17 studies were excluded for the following reasons: not an IHC method (n = 3), insufficient data (n = 5), without outcome of interest (n = 6), data overlapping (n = 3)
Summary
Lung cancer still remains the most common cancer and the most common cause of cancer-related death worldwide. Loss or dysfunction of E-cadherin is associated with an invasive phenotype in numerous cancers [6]. This evidence indicated that E-cadherin may play an important role in the development and progression of NSCLC and might associate with poor prognosis in patients with NSCLC. Many studies have explored the prognostic role and clinicopathological outcomes in patients with NSCLC, but the results remains controversial. Due to the limited sample size and static power in individual study, a meta-analysis is necessary to comprehensively evaluate the prognostic and clinicopathological significance of E-cadherin expression in patients with NSCLC. Many studies have investigated the prognostic role of E-cadherin in patients with NSCLC; the result still remains inconclusive.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
