Abstract
Hyperuricemia is associated with deleterious effects on endothelial dysfunction, oxidative metabolism, platelet adhesiveness, hemorheology, and aggregation
Highlights
Hyperuricemia is associated with deleterious effects on endothelial dysfunction, oxidative metabolism, platelet adhesiveness, hemorheology, and aggregation
The atherosclerotic plaque contains a considerable amount of uric acid which may increase platelet adhesiveness and potentiate thrombus formation [1].There is increasing evidence that elevated serum uric acid levels may predict the development of type 2 diabetes [2]
The results of this study are expected to enhance our knowledge regarding the role of uric acid level on outcomes of patients with carotid artery endarterectomy(CEA)and can be use by clinician in determining patient’s prognosis
Summary
Hyperuricemia is associated with deleterious effects on endothelial dysfunction, oxidative metabolism, platelet adhesiveness, hemorheology, and aggregation. The atherosclerotic plaque contains a considerable amount of uric acid which may increase platelet adhesiveness and potentiate thrombus formation [1].There is increasing evidence that elevated serum uric acid levels may predict the development of type 2 diabetes [2]. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independentpredictor of cardiovascular disease,with many studies in favour [3,4,5] and others against [6,7]. Serum concentrations of uric acid, the product of the metabolism of purine compounds, above 7 mg/dL result in hyperuricemia, causally associated with gout as evidenced in randomized clinical trials using uratelowering therapies [8].
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