Abstract
Our study aimed to investigate the factors affecting the prognosis of patients with mental disorders with COVID-19. All patients with mental disorders who were diagnosed with COVID-19 at the intensive care unit of Wuhan Mental Health Center during the period January 3 to March 1, 2020 were selected. The influence of the baseline characteristics, clinical symptoms, laboratory parameters and the types of mental disorders on prognosis were analyzed. According to their final prognosis, the patients were divided into the deceased group (5 patients) and the cured group (25 patients). The mortality rate of patients with dementia was significantly higher than that of patients with other mental disorders (P = 0.001). The levels of certain laboratory parameters in the serum of dementia patients were significantly increased compared with levels in nondementia patients (WBC count: 10.100±6.147 vs. 5.694±3.383, p = 0.029; neutrophil count: 8.504± 5.993 vs. 3.764 ± 2.733, P = 0.008; BUN: 8.300± 4.072 vs. 4.364 ± 1.196, P = 0.001). Our research indicated that the mortality rate of dementia patients with COVID-19 was higher than that of patients with other mental disorders. A focus on the inflammatory response of dementia patients may provide novel ideas for reducing mortality.
Highlights
An aggressive, acute respiratory disease caused by SARS-CoV-2, a novel coronavirus of zoonotic origin, called COVID-19, has become a new public health crisis threatening the world [1]
The results showed that certain laboratory parameters in the serum of dementia patients were significantly increased (WBC count: 10.100 ± 6.147 vs. 5.694 ± 3.383, P = 0.029; neutrophil count: 8.504 ± 5.993 vs. 3.764 ± 2.733, P = 0.008; blood urea nitrogen (BUN): 8.300 ± 4.072 vs. 4.364 ± 1.196, P = 0.001; Figure 1)
Is there a correlation between the upregulation of inflammation indicators (WBC and neutrophil counts) and the impairment of renal function (BUN)? Our results suggest that WBC and neutrophil counts and BUN levels in nondementia patients were significantly positively correlated (WBC count: r2=0.376, P < 0.05, Figure 2A; neutrophil count: r2=0.325, P < 0.05, Figure 2B)
Summary
Acute respiratory disease caused by SARS-CoV-2, a novel coronavirus of zoonotic origin, called COVID-19, has become a new public health crisis threatening the world [1]. Public health and healthcare professionals are at the frontline and work hard to control and mitigate the spread of the pandemic. With the deepening of the understanding of the disease, patients with COVID-19 in various special groups have gradually attracted attention, such as cancer patients [2, 3], end-stage kidney disease patients [4], and pregnant women [5]. Patients with mental disorders need long-term treatment and specialized care, and their health and psychological status are different from those of the general population. 0.02 < 0.01 0.05 mental disorder and COVID-19 in the pandemic has raised great concerns. Little information about this special group has been reported
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