Abstract
The potential of biopartitioning micellar chromatography (BMC) for screening and analysis of traditional Chinese medicines (TCM) for permeable compounds has been investigated by chromatography of methanolic extracts of Ligusticum chuanxiong, as example. Six other ordinary TCM were also studied. Results showed that more than ten components of Ligusticum chuanxiong extract are significantly retained in BMC. According to relationships between retention in BMC and oral drug absorption, cell-membrane permeability, and blood–brain barrier permeability, the cell-membrane permeability and absorption properties of the permeable components of Ligusticum chuanxiong extract could be predicted from their retention in BMC. Effects on the chromatography of components of Ligusticum chuanxiong methanolic extracts of column temperature, mobile phase pH, and concentration of Brij 35 in the mobile phase are also discussed.
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