Abstract
Several studies have shown that treatment with estrone produces mammary tumors in male mice of the R3 strain in which about 70% of the females develop spontaneous mammary carcinoma. The author experimented with 7 normally ovulating females which were implanted with very small estrone crystals. Daily smears showed all the animals to be in constant estrus until the day of death. 21 male mice of the R3 strain died before 100 days all showing signs of urinary obstruction; 2 animals developed large mammary carcinomas and in both there was a very marked enlargement of the pituitary. Both carcinomas were produced much sooner than any such tumor occurred spontaneously in the female mice. 1 of the tumors was transplanted into 6 male mice of the same strain and grew readily in all. Mammary carcinoma does not seem to occur spontaneously in male mice.
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