Abstract
SummaryA series of 20 rats of the Long-Evans strain which had severe alloxan diabetes for a preliminary period of 2 to 4 months, was given a diet with excess nicotinic acid. The diet was adequate but contained 1 g niacin/kg. The most outstanding effect of this diet was the production of ketonuria in 16 of the 20 animals, although the degree of ketonuria and the response pattern was variable. Supplementary choline did not inhibit ketosis. The action of nicotinic acid in altering fat metabolism is discussed.
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