PRODUCTION OF INTERLEUKINS 1Β, 2, 4, 10 AND C-REACTIVE PROTEIN IN ISCHEMIC STROKE

Abstract

The aim: The aim of this study was to determine the content of interleukins (IL) 1β, 2, 4, and 10, as well as the generally accepted marker of inflammation - C-reactive protein (CRP) - in the peripheral blood on the first and tenth days of ischemic stroke (IS). Materials and methods: The study involved 25 patients with IS (including 8 people with mild case of neurological disorders, 9 – moderate case and 8 – severe case) and 14 people of the control group. The levels of IL-1β, IL-2, IL-4 and IL-10 in the blood were determined by the immunoenzyme method. Results: It was found that on the first day in patients with IS an increase in the concentration of CRP and all the studied cytokines, especially pro-inflammatory cytokines IL-1β and IL-2, is marked. On the tenth day, the content of pro-inflammatory cytokines and CRP significantly decreases compared to the first day, but remains higher than in the control, but the concentration of anti-inflammatory cytokines (IL-4 and IL-10) continues to increase. Conclusions: The results obtained on the first day of IS indicate the development of neuroinflammation. On the tenth day the severity of the inflammatory process is significantly reduced, but it still occurs. It was also shown that the outcome of IS depends on the concentration of cytokines in the blood: the higher the level of pro-inflammatory interleukins on the first day, the lower the content of anti-inflammatory interleukins and the higher the amount of pro-inflammatory interleukins on the tenth day, the more pronounced the neurological deficit.