Abstract
Prolonged ethanol ingestion by adult rats resulted in an inhibition of amino acid incorporation in vitro by liver membrane-bound ribosomes. The same treatment, however, produced a stimulation in the activity of free ribosomes. The addition of endoplasmic reticulum membranes, extracted from the microsomal fraction of control or ethanol-treated rats, had an inhibitory effect on the protein synthetic activities of free ribosomes. However, the membrane preparations from the livers of ethanol-treated animals had relatively greater inhibitory activity if compared with the similar preparation from the control livers. The observed effect of ethanol intake on liver protein synthesis in vitro could be almost completely reversed if the animals abstained from ethanol for a period of 4 weeks.
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