Abstract

Bioprocesses are important biological reactions which need several sophisticated methods and equipment to produce many novel and important compounds which some of them are traditionally produced by synthetic chemical reactions. In bioprocesses, the products are often produced in a dilute environment and finally they require a high purity. Because of that, downstream processes are usually included a large number of separation steps. Size and capital costs of the equipment are two main limitations of using bioprocesses at industrial scale. Bioprocess intensification by minimizing, substitution, moderation and simplification of the methods and equipment, drastically leads to sustainable processes. This study looks at intensification of the emerging equipment and operational methods and their advantages to lead smaller and cleaner bioprocess plants which in turn, increases production efficiency and quality and decreases byproducts formation, capital cost and energy consumption.

Highlights

  • The need for sustainable, efficient and cost effective processes are in demand for many chemical and biological industries (Wohlgemuth, 2009)

  • Process Intensification (PI) has been known as a method to comply with such requirements (Lutze et al, 2010)

  • One of several definitions of PI sets out a selection of all themes is that “Any chemical engineering development that leads to a substantially smaller, cleaner, safer and more energy efficient technology is process intensification” (Reay et al, 2013)

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Summary

Introduction

The need for sustainable, efficient and cost effective processes are in demand for many chemical and biological industries (Wohlgemuth, 2009). Process intensification as a method for making significant changes in the size of a process plants to achieve a given production objective. These reductions can come from decreasing the size of individual equipment or from removing the number of involved unit operations (Stankiewicz and Moulijn, 2000). PI refers to replace complex technologies with integrated equipment and processes that are smaller in size, less costly and more efficient (Charpentier, 2007) It integrates as many unit operations as possible into a multifunctional ones to be used in the chemical and biological industries (Marques and Fernandes, 2011). We define what it involves and review recent developments in bioprocess-intensifying devices and methods

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