Abstract
Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part two
Highlights
Behçet’s disease is a complex multisystemic disease with variable vasculitis
Laboratory changes: leukocytosis 7 cases (20,8 ± 4,3G/l), anemia - 6, erythrocyte sedimentation rate (ESR) increased in all cases 44.6 ± 13.2 mm/h, C-reactive protein (CRP) 21, 2 ± 6.1 mg/l, hypereosinophilia was noted in 1 patient, hypertransaminase in 2, increased creatinine level in 2, hypercoagulation in 4, hemoculture, procalcitonin, complementation - all was normal, APLAB in 1 case revealed lupus anticoagulant, antinuclear antibody (ANA), aDNA, aNRP in all patients were negative, antibodies to MP3 were positive in 2 cases, in the same patients there was rheumatoid factor (RF) +, markers of viral hepatitis were not detected s in any patient
Canakinumab showed a sustained therapeutic effect and no meaningful differences in safety profiles were noted across all age grps. These analyses suggest that a canakinumab body-weight adjusted regimen at the dose of 4 mg/kg every 4 weeks offers similar safety and efficacy in adult-onset Still’s disease (AOSD) pts to that observed in systemic juvenile idiopathic arthritis (SJIA) pts
Summary
Behçet’s disease is a complex multisystemic disease with variable vasculitis. The disease is most prevalent in the Eastern Mediterranean, the Middle East, and East Asia, along the ancient Silk Road. Further analysis of HSP patients with acute scrotal involvement (n = 27) compared to those without this complication (n = 122) at diagnosis revealed that the median of current age [4.9 (1.7-12.6) vs 6.1 (0.9-14.8) years, p = 0.201] and purpura duration [18.5 (5-60) vs 14 (1120) days, p = 0.101] were similar in both groups. Objectives: This study was performed with the aim to develop an index (disease recurrence index) serving to determine the common clinical and laboratory features of HSP and to predict the risk of recurrence on the base of signs observed at the onset of clinical course. Objectives: We report a case of Kawasaki disease with concurrent salmonella infection and a dengue positive serology Methods: A two-year-old male child presented with a history of fever for 7 days, irritability and abdominal distension since 2 days.
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