Abstract
Issues previously ignored, but particularly pertinent to brain tissue grafting in aging subjects are presented. These primarily include questions regarding possible idiosyncracies in aging and degenerative brain which might cause special problems as a host organ, and how one logically and ethically proceeds from preliminary studies in rodents, through more sophisticated primate models, eventually into tests in clinical patients with neurodegenerative diseases. Answers to these and similar questions are bound to influence the continued development of this field and its possible utility in treating human CNS diseases.
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