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Abstract
ABSTRACT This study investigates the antifungal potential of a probiotic yeast isolated from traditionally fermented green gram dosa batter. Among 20 isolates, MYSSBYPS10, identified as Pichia kudriavzevii, exhibited significant antifungal activity against Macrophomina phaseolina, Aspergillus niger, and Fusarium oxysporum. MYSSBYPS10 showed over 68% survival in acidic pH and bile conditions, with no sensitivity to simulated gastric juice. The isolate demonstrated >90% autoaggregation and cell surface hydrophobicity, resistance to antimicrobial drugs, and susceptibility to antifungal drugs. It also exhibited no hemolytic or gelatinase activity, indicating safety. Inhibition assays revealed 69.14% growth inhibition of M. phaseolina, 64.72% of A. niger, and 68.60% of F. oxysporum. The Volatile Organic Compounds (VOCs) produced by MYSSBYPS10 inhibited fungal growth by 44.70% (M. phaseolina), 56.19% (A. niger), and 54.64% (F. oxysporum). SEM analysis showed inhibition of M. phaseolina, highlighting MYSSBYPS10’s potential as a probiotic with antifungal properties.
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