Abstract
A 44-year-old man consulted an internist because of abnormalities in an upper gastrointestinal series. It showed an elevated lesion with central depression in the greater curvature of the middle part of the stomach. Upper gastrointestinal endoscopy showed an elevated lesion with central depression, bridging hold, and no abnormalities of the gastric mucosa in the greater curvature of the middle part of the stomach. Endoscopic ultrasonography showed a submucosal tumor derived from the muscle layer of the stomach. Computed tomography showed a 22-mm tumor in the upper part of the stomach. Integrated position emission tomography/computed tomography (PET/CT) showed an intense tracer uptake by the tumor. Based on these findings, a gastrointestinal stromal tumor was suspected and laparoscopic endoscopic cooperative surgery was performed. A histopathological examination showed lymphoplasmacytic infiltration and fibrosis, and an immunohistochemical analysis showed the infiltration of IgG4-positive lymphoplasmacytic cells. The probable diagnosis was IgG4-related sclerosing disease of the stomach. We herein describe a rare case of probable IgG4-related sclerosing disease which presented as a gastric submucosal tumor. PET/CT is a useful imaging technique for the diagnosis and follow-up of this disease.
Highlights
IgG4-related sclerosing disease is a systemic disease characterized by the extensive infiltration of IgG4-positive plasma cells and lymphocytes in various organs [1]
It has been reported that position emission tomography/computed tomography (PET/ CT) is useful for the localized diagnosis of this disease [3]
We present a case of probable IgG4-related sclerosing disease presenting as a gastric submucosal tumor with an intense tracer uptake on position emission tomography/computed tomography (PET/CT)
Summary
IgG4-related sclerosing disease is a systemic disease characterized by the extensive infiltration of IgG4-positive plasma cells and lymphocytes in various organs [1]. We present a case of probable IgG4-related sclerosing disease presenting as a gastric submucosal tumor with an intense tracer uptake on PET/CT. Case presentation A 44-year-old man consulted an internist due to abnormalities on an upper gastrointestinal series. Upper gastrointestinal endoscopy showed an elevated lesion with central depression, bridging hold, and no abnormalities of the gastric mucosa in the greater curvature of the middle part of the stomach (Fig. 1a). The patient was diagnosed with probable IgG4-related sclerosing disease of the stomach. The patient made an uneventful recovery and was discharged on postoperative day 7 He was examined in a clinic 7 weeks after surgery and was found to have made a full recovery.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
