Abstract
The commonest cause of death from advanced colorectal cancer is disease progression of hepatic metastases. Radiotherapy is an important treatment modality in locally advanced colorectal cancer. Radioembolisation (RE) is a technique for administering resin or glass microspheres that contain yttrium-90 to unresectable primary or secondary hepatic malignancies internally via the liver’s arterial supply in a single procedure. It can be considered a form of selective internal radiotherapy (SIRT) or arterially-administered brachytherapy. Clinical trials of RE used with concomitant radiosensitising chemotherapy have shown promising results in patients with metastatic colorectal cancer. In this chapter, the scientific rationale for combining RE with chemotherapy is outlined and the evidence base for combining RE with systemic chemotherapy in the treatment of metastatic colorectal cancer is appraised.
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