Abstract
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43–0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71–0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.
Highlights
Esophageal cancer is considered one of the most aggressive cancers in the world
Considering that esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma, as well as of squamous cell carcinoma, we have examined all the papers related to other types of esophageal carcinoma (i.e. esophageal adenocarcinoma (EADC)) or squamous cell carcinoma apart from ESCC
We evaluated the association between five genetic variations in pri/pre-microRNA and the risk of ESCC in a Chinese population
Summary
Esophageal cancer is considered one of the most aggressive cancers in the world It includes two main types: esophageal adenocarcinoma (EADC) and esophageal squamous cell carcinoma (ESCC) [1]. Only a subset of individuals would develop esophageal cancer under the environmental risk factors. A series of single nucleotide polymorphisms (SNPs) were found to be associated with the risk of ESCC in studies with different designs and populations, and results were not consistency. It indicated that the genetic etiology of ESCC is complicated, and further independent investigation is needed to confirm the associations with ESCC risk
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